Lindsay Wagahoff, MA | Aug 19, 2020 | 0
“Lateral epicondylopathy,” formerly “lateral epicondylitis, is a painful irritation of the common origin of the wrist extensor muscles. Lateral epicondylopathy (LE) is the most common cause of elbow pain. (1) The condition is related to repetitive wrist extension and is commonly referred to as “tennis elbow,” although the majority of those affected do not play tennis. (2)
The common extensor tendon originates on the lateral epicondyle and lateral supracondylar ridge of the humerus, and consists of the fused tendons of the extensor carpi radialis brevis, extensor digitorum, extensor digiti minimi, and extensor carpi ulnaris (from lateral to medial). Nearly all forces associated with wrist extension are funneled through this tendon onto lateral epicondyle. The supinator muscle lies deep to the common extensor group, with some fibers attaching to the lateral epicondyle. (3) The common extensor tendon, particularly the extensor carpi radialis brevis (ECRB), is relatively hypovascular, creating a tendency for injury and hypoxic degeneration. (4,5)
The pathogenesis of lateral epicondylopathy entails repetitive wrist extension, causing micro-tearing of the common extensor tendon, ultimately leading to a failed healing response and degeneration. (4,5) The primary site of injury is the extensor carpi radialis brevis (ECRB) tendon, 1-2 cm distal to its attachment on the lateral epicondyle. (4,6,7) While acute inflammation may accompany the earliest phase of tendon disease, it is unlikely to last more than a few days. (8) In chronic cases, inflammatory cells are absent. (2,8-11) Researchers now recognize that repetitive microtrauma does not cause inflammation, but rather a failure of the natural healing process, resulting in a disorganized pathological tendon degeneration, called “angioblastic degeneration.” (8,9,11-15) Since LE is primarily a degenerative condition, rather than a chronic inflammatory process as once hypothesized, the term “tendinitis” has been replaced with “tendonosis” or “tendinopathy.”. (8,10-14) True tendinitis is rare compared to tendinopathy. (16) A degenerated tendon may be predisposed to partial or full thickness tears as a result of ongoing strain, particularly rapid, eccentric overload. (15)
Lateral epicondylopathy affects between 1 and 3% of the general population each year. (1,17) The condition occurs predominantly in the fourth or fifth decade and affects men and women equally. (1,18) LE strikes the dominant arm in 75% of cases. (18) LE results in an average of 12 weeks of disability in up to 30% of those workers affected. (19)
LE is a byproduct of excessive force or repetitive movement, combined with improper biomechanics and/or posture. (20,21) The primary risk factors for LE include repeated wrist extension and forearm supination/pronation. Certain occupations and activities are predisposed, including carpenters, bricklayers, seamstresses, tailors, pianists, drummers, those who shake hands excessively (politicians), and those who perform prolonged keyboard or mouse work. (22) Only 5% of lateral epicondylopathy patients participate in racquet sports (20), but among tennis players, 50-60% will be affected at some point in their career. (18) LE injuries related to tennis are thought to develop as a result of improper mechanics during backhands or serves. (23) Additional racquet-related risk factors include: using a new, heavy, or tightly strung racquet, excessive grip size, and hitting wet or heavy tennis balls. (22)
Symptoms often begin insidiously following overuse-type activity, without a history of specific trauma. The classic clinical presentation includes pain over the lateral aspect of the elbow. (22,25) Symptoms are typically provoked by activities that involve gripping and/or wrist extension. (25) Pain may vary from mild to sharp, severe pain that limits the simplest activities, like picking up a coffee cup. Rest may provide relief. (22) Symptoms and objective progress may be tracked on a DASH questionnaire or Patient-Rated Tennis Elbow Evaluation (PRTEE). (27)
Pain is generally localized, and clinicians should consider the possibility of peripheral neuropathy (radial tunnel syndrome) in patients whose symptoms radiate distally. Radial tunnel syndrome is entrapment of the radial nerve as it passes through the proximal forearm near the lateral epicondyle. Common sites of compression within the radial tunnel include the Arcade of Frohse, or within the supinator muscle. Research suggests that up to 10% of patients with lateral epicondylopathy have co-existent radial tunnel syndrome. (28) The similarities of lateral epicondylitis and radial tunnel syndrome can make differentiation of the two conditions challenging. The pain of radial tunnel syndrome should be more acute distally. (29) Nocturnal pain is more common in radial tunnel patients than those with lateral epicondylitis. (30)
The classic clinical findings for LE include pain on palpation of the lateral epicondyle, pain on resisted wrist extension, and pain on resisted middle finger extension. (31) Peak tenderness is located directly over, and slightly distal to, the lateral epicondyle, most specifically over the origin of the ECRB. Cozen’s test is basically wrist extension performed with the patient’s fist closed and elbow fully extended. The reproduction of pain upon this maneuver suggests lateral epicondylopathy. When Cozen’s maneuver produces pain when performed with the elbow slightly bent, the condition may be more challenging to manage. Mill’s test for LE involves passive stretching of the wrist extensors while the elbow is in extension. Resisted extension of the middle finger (resisted long finger extension test) places tensile stress on the ECRB tendon and often provokes LE symptoms. Clinicians should consider radial tunnel syndrome when this maneuver is more painful than Mill’s test.
Neurologic assessment should be performed to identify the possibility of cervical radiculopathy or peripheral neuropathy. Radial tunnel syndrome may manifest as diminished sensitivity along the dorsal aspect of the forearm and/or thumb, or weakness of thumb extension. (32,33)
Plain film radiography is of little diagnostic value for the assessment of soft tissue disorders. (34) Radiographs may be appropriate in the presence of “red flags” or a history of trauma, to rule out fracture, dislocation, infection, or neoplasm. (34,35) Occasionally, radiographs may demonstrate calcific tendinitis or the presence of intra-articular pathology. (35) MRI has the ability to demonstrate tendinosis as well as bony or soft tissue pathology. Diagnostic ultrasound is useful for evaluating the common extensor tendon for tendinitis or tearing. (35)
The differential diagnosis of lateral epicondylopathy includes cervical radiculopathy, radial tunnel syndrome, osteoarthritis, fracture, infection, neoplasm, osteochondral loose body, elbow synovitis, triceps tendinitis, sprain/strain, myofascial pain syndrome, and inflammatory arthropathy.
The natural course of lateral epicondylopathy can be exasperating. Twenty percent of untreated patients demonstrate no improvement after one year. (36) Even those patients undergoing optimal management may require three to four months for a full recovery. (16) Evidence supports the use of traditional conservative measures, including manipulation, mobilization, exercise, friction massage, bracing, and modalities. (38,39)
Initially, patients may require selective rest and avoidance of activities involving repetitive wrist extension, pronation, or supination. Counter-irritant creams may provide palliative relief. Ice or home ice massage may be helpful for acute “tendinitis” patients, but do little to alter the long-term course of chronic tendinopathy. Tennis players should look for ways to improve mechanics, including not leading with their elbows and switching to a 2-hand backstroke that limits pronation. (23) The use of a counter-force strap applied firmly approximately 10 cm distal to the elbow joint, has been shown to decrease pain and improve grip strength. (40-42) Counter-force braces should not be used in cases of concurrent radial tunnel syndrome, as the additional pressure will likely exacerbate compressive neuropathy symptoms. Some clinicians choose to employ a cock-up wrist splint, although this orthotic has less support in the literature. (42,43)
There is moderate evidence supporting the use of mobilization/manipulation of the elbow, cervical spine, and wrist for the treatment of LE. (44-54) Mobilization/ manipulation of the elbow demonstrates an immediate decrease in pain and a substantial increase in pain-free grip. (45,46,54) Various techniques are employed for restoring elbow mobility, including McKenzie Directional Therapy (MDT), Mulligan mobilization, and Mill’s manipulation, which is performed as a high-velocity thrust to the extended elbow while the wrist and hand are flexed. (55) Some studies suggest that mobilization or manipulation of the wrist may be as effective as a conventional local treatment for lateral epicondylopathy. (52,53) Manipulation of the cervical and cervicothoracic region has been shown to decrease pain and disability in lateral epicondylopathy patients. (47-49,51)
Any tendinosis is associated with excessive, disorganized collagen formation, scarring, and contracture of peritendinous tissue. (51) IASTM is thought to help mobilize scar tissue and increase pliability by re-initiating an inflammatory process through controlled microtrauma. (51,56) The use of IASTM has demonstrated “significantly better” outcomes than exercise alone, with 57% resolution of complaints after one month of care, and 78% resolution after two months. (57) Anecdotal evidence suggests that dry needling may be a useful alternative for recalcitrant cases.
Myofascial release is an effective treatment for lateral epicondylopathy. (71) STM and stretching exercises should be directed at the wrist extensors and supinator muscle. Resistance training may begin isometrically and advance to eccentric exercise. All outcome measures for the treatment of lateral epicondylopathy show improvement with the addition of eccentric wrist extensor strengthening. (43) Eccentric strengthening is thought to stimulate collagen metabolism and synthesis. (43,58) The “Tyler Twist” exercise, utilizing a Theraband Flexbar, is a novel approach to eccentric strengthening that has shown significant pain reduction and excellent outcomes in limited trials. (69,70)
Some clinicians advocate the use of low-level laser, ultrasound, phonophoresis, iontophoresis, elastic therapeutic tape and acupuncture for the treatment of lateral epicondylopathy. (38,43) More recent concepts for the management of LE include the application of a glycerol trinitrate patch, which has been shown to decrease pain and enhance healing while stimulating collagen synthesis. (43,59)
Medical management includes the use of oral or topical NSAIDs. (43,60) Autologous or platelet-enriched-plasma (PRP) injections have been advocated for the treatment of lateral epicondylopathy (61), but remain unproven. (62,63) While corticoid steroid injections may provide some short-term benefit, these injections can be detrimental to long-term recovery. (64) One study demonstrated that corticosteroid injections significantly reduce pain, with 78% success at six weeks (versus 65% improvement for standard physical therapy.) (65) Unfortunately, the same study demonstrated that at one year, those patients treated by injection were “significantly worse,” compared to those managed conventionally or those who underwent no treatment. (65)
Less than 11% of patients will require surgical intervention. (36) Factors associated with a poor prognosis for conservative care include heavy manual labor, lateral epicondylopathy in the dominant arm, high pain perception, and poor coping strategies. (36) Ultrasound-guided percutaneous radiofrequency thermal lesioning (RTL) is a minimally-invasive surgical procedure used to stimulate healing. Studies regarding RTL management of LE demonstrate significant pain reduction and grip strength improvement, with 85% of patients reporting pain relief after one month, and 91% reporting good to excellent satisfaction after six months. (66) Surgical intervention, including arthroscopic removal of the pathologic tendon tissue, has demonstrated success, but should only be considered after six months of failed conservative care. (67)
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